2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

PDF 2.47 MB

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1874):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W587829
    4-Thiothymidine
    		99.67%
    4-Thiothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4-Thiothymidine
  • HY-W011725
    N-6-Methyl-2-deoxyadenosine
    		99.83%
    N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N-6-Methyl-2-deoxyadenosine
  • HY-B0228S13
    Adenosine-13C10
    		Chemical 99.63%
    Adenosine-13C10 (Adenine riboside-13C10; D-Adenosine-13C10) is 13C-labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
    Adenosine-<sup>13</sup>C<sub>10</sub>
  • HY-W141394
    Bz-OMe-rA
    		99.34%
    Bz-OMe-rA is a nucleoside analog.
    Bz-OMe-rA
  • HY-B0228R
    Adenosine (Standard)
    		Chemical
    Adenosine (Standard) is the analytical standard of Adenosine. This product is intended for research and analytical applications. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
    Adenosine (Standard)
  • HY-119499
    6-Thioguanosine
    		98.23%
    6-Thioguanosine (6-Mercaptoguanosine), an active nucleoside, is an Azathioprine metabolite. 6-Thioguanosine has immunosuppressive effects.
    6-Thioguanosine
  • HY-16776
    Censavudine
    		98.71%
    Censavudine (OBP-601; BMS-986001), a nucleoside analog, is a nucleoside reverse transcriptase inhibitor. Censavudine is a potent HIV inhibitor with EC50 ranges from 30 nM to 81 nM and 450 nM to 890 nM for HIV-2 and HIV-1, respectively. Censavudine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Censavudine
  • HY-15228
    RX-3117
    		Inhibitor 99.25%
    RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis.
    RX-3117
  • HY-W011125
    Bz-dA
    Bz-dA (N6-Benzoyl-2'-deoxyadenosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides
    Bz-dA
  • HY-103185
    CCPA
    		99.77%
    CCPA (2-Chloro-N6-cyclopentyladenosine) a highly selective A1 adenosine receptors agonist with a Ki of 0.4 nM. CCPA selectively binds to adenosine A1 over adenosine A2 receptors (Ki of 3900 nM). CCPA is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    CCPA
  • HY-17564
    2'-Deoxycytidine hydrochloride
    		99.98%
    2'-Deoxycytidine hydrochloride is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose.
    2'-Deoxycytidine hydrochloride
  • HY-112581
    5-Methoxyuridine
    		99.98%
    5-Methoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Methoxyuridine
  • HY-W114787
    N4-Benzoyl-2’-O-methylcytidine
    		99.26%
    N4-Benzoyl-2’-O-methylcytidine is a natural cytidine nucleoside analog. Cytidine analogs have the mechanism of inhibiting DNA methyltransferase (such as Zebularine (HY-13420)) and have potential antimetabolite and antitumor activities.
    N4-Benzoyl-2’-O-methylcytidine
  • HY-B0228S
    Adenosine-d
    		Chemical 99.72%
    Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
    Adenosine-d
  • HY-W008552
    2-Iodoadenosine
    		99.21%
    2-Iodoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2-Iodoadenosine
  • HY-W130466
    N4-Methylcytidine
    		99.99%
    N4-Methylcytidine (Nsc518744) is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    N4-Methylcytidine
  • HY-W008848
    DMT-dG(ib) Phosphoramidite
    		99.71%
    DMT-dG(ib) Phosphoramidite is a phosphoramidite monomer that can be used in the synthesis of DNA and related molecules.
    DMT-dG(ib) Phosphoramidite
  • HY-102071
    KIN59
    		Inhibitor ≥99.0%
    KIN59 (5’-O-Tritylinosine) is a potent thymidine phosphorylase allosteric inhibitor. KIN59 inhibits FGF2-stimulated cell growth. KIN59 inhibits the expression of p-FGFR1, P-Akt in FGF2 (10 ng/mL) stimulated cells. KIN59 shows anti-tumor activity.
    KIN59
  • HY-13640
    Rabacfosadine
    		99.26%
    Rabacfosadine (GS-9219), a novel proagent of the nucleotide analogue PMEG, is designed as a cytotoxic agent that preferentially targets lymphoid cells.
    Rabacfosadine
  • HY-W570888
    2'-O,4'-C-Methylenecytidine
    		98.59%
    2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands.
    2'-O,4'-C-Methylenecytidine